hormone sensitive lipase

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The Science behind Raspberry Ketones

Who can resist the beauty of a red raspberry?  Their aroma is just as nice.  And what an amazing discovery, the power of the ketone molecule in that aroma!  Raspberry ketones are very small molecules called “phenols”.  They are found in raspberries, and also cranberries, 200px-Raspberry_ketoneblackberries, and anise.  Here is a little bit of the science behind the miracle of raspberry ketones.

Studies show Raspberry Ketones (RK) increase the breakdown of fat tissue directly with these two methods:

  1. Increasing the secretion of adiponectin in fat cells
  2. Increasing norepinephrine induced hormone-sensitive lipase (HSL)

Adiponectin is a hormone secreted by fat cells.  It is found in high amounts in thinner people and lower amounts in those that are overweight.  Adiponectin increases glucose uptake by the cells, increases insulin sensitivity, protects blood vessels from damage, and stimulates the break down lipids in fat tissue.   This shows promise for persons with Type 2 Diabetes, which is increasing in developing countries, and often exists undiagnosed.  Nonalcoholic steatohepatitis (NASH) or fatty liver is a condition related to diabetes, RK shows promise in protecting the liver from damage, improving cholesterol profiles, reversing insulin resistance and increasing overall anti-oxidant capacity.

What else can increase adiponectin?  Daily low mercury fish intake, a high fiber diet, and plenty of exercise!

Hormone-sensitive lipase (HSL) is needed to move fat stores into usable energy forms.  It is stimulated by norepinephrine, and inhibited by insulin.  Overweight or obese individuals (pre-diabetic) often have high levels of insulin, which makes it difficult for them to lose weight.  RK has been shown to stimulate HSL to move from the inside of the cell to the fatty tissues to break them down.   These findings were from animal studies, no human trials could be found.

What else can increase hormone sensitive lipase?  Aerobic exercise!

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